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Collagen is effective on proteases
Collagen is essential for new tissue generation. This family of structural proteins attracts cells to the wound area and forms the underlying layer for cell adhesion that induces cell growth and helps build new proteins.
During the wound healing process, there are three main phases: inflammatory, granulation, and wound closure.
PROMOGRAN™ Matrix Wound Dressing with ORC/Collagen
is an absorbent, open-pored sterile, freeze-dried hexagonal matrix composed of 45% ORC and 55% bovine collagen.
PROMOGRAN PRISMA™ Matrix ORC with ORC/Collagen/Silver
is a sterile, freeze-dried composite that consists of 44% ORC, 55% bovine collagen, and 1% Silver/ORC of which 1/4 of the total weight of the Silver/ORC is silver (Figure 1). Thus, PROMOGRAN PRISMATM Matrix contains 0.25% w/w total silver.
Clinically proven healing power in hundreds of patients for over 10 years
Product Evidence ¹
• Published clinical data, wound fluid data, and in vitro data
• 13 RCTs and numerous clinical studies showing that Collagen/ORC helps heal wounds
• ORC/Collagen/Silver – The benefits of silver in helping protect against infection
• Clinically proven over 10 years
PROMOGRAN PRISMA™ Matrix can be used prior to applying a skin graft (or equivalent) to prepare the wound and help promote granulation tissue formation so skin graft take is optimal. ²⁻³
References:
1. 3M Medical Publications database. June 2018.
2. Weidenhagen R. Clinical experience with PROMOGRAN PRISMA. Poster presented at European Wound Management Association (EWMA); May 2-4,2007; Glasgow, UK.
3. Tausche AK & Sebastian G. Wound conditioning of a deep tissue defect including exposed bone after tumor excision using PROMOGRAN matrix, a protease-modulating matrix. Int Wound J 2005; 2(3): 253-257.
4. PROMOGRAN™ MATRIX Family Monograph. San Antonio, TX: 3M Licensing, Inc. and Systagenix Wound Management; 2016.
5. Treadwell TA, Fuentes MI, Walker D. Wound bed preparation prior to the use of bi-layered tissue engineered skin: The Role of Protease Modulation. Wound Rep Reg. 2008;16:A19.
